Patients suffering from neck pain often seek effective treatments to alleviate their discomfort. Musculoskeletal manipulations have been proposed as a potential solution for this issue. However, the effectiveness of these manipulations can vary significantly among individuals. A systematic review and network meta-analysis can provide valuable insights into the comparative effectiveness of different manipulation techniques. Understanding these differences is crucial for healthcare providers to recommend the most suitable treatment options. Ultimately, improving treatment outcomes for neck pain patients is a priority for healthcare professionals.